Antimicrobial and toxicological evaluation of Origanum vulgare: an in vivo study

Abstract Origanum vulgare has been of great interest in academia and pharma industry due to its antioxidant, antifungal antitumor properties. The present study aimed find the anti-MRSA potential vivo toxicity assessments O. vulgare. extract was used monitor activity mice. Following MRSA established infection mice (Mus musculus), treatment with continued for 7 days. Autopsies were performed re-isolation, gross lesion scoring bacterial load various organs measured. Additionally, blood sample analysed hematological assays. Toxicity assessment as medicine done at 200 mg/kg 400 by evaluating liver kidney functions. Bacterial lungs heart significantly low compared positive control following treatment. Likewise, treated groups had hematological, neutrophil TLC values similar groups. Increased AST, ALP total bilirubin alongwith marked hepatocellular degeneration distortion around central vein, inflammatory cell infiltration, cytoplasmic vacuolization hepatic cells observed higher dose. It is concluded that crude may contain beneficial secondary metabolites future be explored curing infectious diseases.